Incyte’s Atopic Dermatitis Studies Of Ruxolitinib Cream Show Clinically Meaningful Improvements

(RTTNews) – Incyte Corp.’s (INCY) ruxolitinib cream showed clinically meaningful improvements in patient-reported quality of life assessments, as per its phase 3 TRuE-AD1 and TRuE-AD2 atopic dermatitis studies results.

The studies evaluate ruxolitinib cream for the treatment of patients with mild-to-moderate atopic dermatitis.

The overall safety profile of ruxolitinib cream was consistent with previously reported data, with no new safety signals observed in the pooled analysis, the company said in a statement.

The new, pooled data reinforce that treatment with ruxolitinib cream resulted in a rapid, substantial and sustained reduction in itch; and improved the extent and severity of AD as measured by the Eczema Area Severity Index (EASI) and Scoring Atopic Dermatitis assessment tools.

The results also demonstrated improvement in patient-reported perceptions of sleep quality, sleep depth and restoration associated with sleep as measured by the PROMIS Short Form-Sleep Disturbance (8b) questionnaire.
Atopic dermatitis is a chronic inflammatory skin condition that may result in decreased quality of life for patients; attributable in part to sleep disturbances resulting from intense and persistent itch.

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